Ethanol induced gu in animal model resembles the pathophysiology of human ulcer. Alphalipoic acid improves acetic acidinduced gastric. Folic acid supplementation ameliorates inflammation and. Ethanolinduced gastric ulceration in rats semantic scholar. Zingerone is an ingredient of ginger zingiber officinale with different pharmacological activities. We have investigated this mechanism in the rat stomach via gross morphologic, videomicroscopic, histochemical, and pharmacologic approaches. The preliminary phytochemical evaluation was carried out by standard methods. Cyathula prostrata on ethanol induced gastric ulcer in rats ethanol induced ulcer in rats were valuated as described by ode and asuzu 2011 15. Ethanol causes necrotic lesions that reduce gastrointestinal tract defensive factors like bicarbonate secretion and the production of mucus and its circulation 2224. Gastric ulcers were induced by ethanol 96%, 5 mlkg, po in male wistar rats and zingerone 50, 100, and 200 mgkg. The albino rats of either sex were divided into five groups, each consisting of six rats. The effect of nicotine on ethanolinduced gastric ulcers in rats. Acute gastritis or gastric ulcer was induced in the rat stomach by 80% ethanol or 60% acetic acid, respectively.
Antioxidant effects of some drugs on ethanol induced ulcers author. Mechanisms of gastroprotective effects of ethanolic leaf extract of. Rjpt gastro protective effect of standardized ethanolic. The results of the current research revealed that following fed the rats with biochanin a the protein concentration preserved in the homogenate stomach tissue. Normal saline and ranitidine were used as negative and positive control. The aim of this work was to investigate the antioxidant potential of some commonly used drugs bromocriptine, haloperidol and azithromycin on alcohol induced ulcers in the rat.
This agent is also effective as mucosal protection in treatment of nonacid depended models such as ethanol induced ulcer model 3, 7, 30. The present study was designed to investigate the cytoprotective and antiinflammatory properties of tertbutylhydroquinone tbhq, a nuclear factor erythroid 2related factor 2 nrf2 activator, against gastric mucosal damage induced by acute exposure of ethanol. Gastric ulcer, protective effect, ethanol falcaria vulgaris locally named ghazzyaghi poghazeh is a member of umbelliferae family which grows near farmlands and is consumed as a vegetable in some regions of iran. Evaluation of the antiulcer effect of aerva javanica. October 1997 smokingethanol and gastric mucosal damage 1189 potentiate both ethanol and stressinduced gastric muexperiment. Evaluation of antiulcer activity of methanolic extract of. Research article ethanolinduced gastric ulcer in male. Daniel hollander and his colleagues induced ulcer with ethanol in rats to evaluate the gastroprotective. In the present study we investigated the gastroprotective effect of citrus sinensis peel aqueous extract cspe and hesperidin h in ethanol etoh induced oxidative stress and peptic ulcer in rats.
Studies on the mechanism of ethanolinduced gastric damage in rats. Jasminum sambac is used in folk medicine as the treatment of many diseases. Evaluation of gastroprotective activity of myristica. Ethanol induced ulcer model 22 the ulcer was induced by administering ethanol.
In this study, the preventive effects of the crude extract of scutia buxifolia cesb against gastric ulcer induced by 70% ethanol were evaluated in male wistar rats. The gastro protective effects of cibotium barometz hair on. Ulceration was induced by oral administration of absolute ethanol 1cm3kg body weight. Amelioration of ethanolinduced gastric ulcers in rats pretreated. At creative biolabs, we offer ethanolinduced gastric ulcer models induced in both rats and mice. Evaluation of preventive effect of withania somnifera root. Several studies have investigated the effect of zingerone on various gastrointestinal diseases, including irritable bowel syndrome and diarrhea. The effect of oral administration of raw camel milk 5 mlkg b. Methanol leaf extract of actinodaphne sesquipedalis lauraceae enhances gastric defense against ethanolinduced ulcer in rats hanita omar,1,2 noraziah nordin,3 pouya hassandarvish,4 maryam hajrezaie,5 ainnul hamidah syahadah azizan,1 mehran fadaeinasab,6 nazia abdul majid,7 mahmood ameen abdulla,5 najihah mohd hashim,3 hapipah mohd ali1 1department of chemistry, faculty of. Therapeutic effect of low molecular weight chitosan. Roles of nitric oxide in protective effect of berberine in.
Introduction of peptic ulcer peptic ulcer is among the most predominant gastrointestinal diseases in the world and is characterized by ulceration in the stomach and duodenum. Pdf amelioration of ethanolinduced gastric ulcers in. Suppressive effect of melatonin administration on ethanol. Oral administration of camel milk in rats with ethanolinduced gastric ulcer. Ethanolinduced gastric ulcer in rats and intervention of. Results antiulcer study gross estimations the results that pretreated with c. Biochanin a gastroprotective effects in ethanolinduced. Concentrated ethanol causes gastric lesions by a mechanism that is poorly understood. Administration with weac not only markedly increased the activities of cat, sod, and gsh, decreased the level of mda, but also reduced the productions of tnf. Antioxidative and antiinflammatory effects of water.
By 5 min, hyperemia greatly intensified at some mucosal sites. Gastroprotective effect of zingerone on ethanolinduced gastric ulcers in rats article pdf available in medicina kaunas, lithuania 553. Research article gastroprotective effects of lion s mane. Evaluation of preventive effect of withania somnifera root extract against ethanol induced ulcers in rats. Diosmin protects against ethanolinduced gastric injury in. In this study, we determine the cytotoxic, antioxidant and gastroprotective effect of ethab against ethanolinduced gastric mucosal ulcer in rats.
Gastroprotective activity of ethyl43,5ditertbutyl2. Pdf gastroprotective effects of pistacia atlantica extract on. Histological analyses and studies of antioxidant and antiinflammatory activities were. Antioxidative and antiinflammatory effects of water extract. Aphyllophoromycetideae extract against ethanolinduced ulcer in rats jingyangwong, 1,2 mahmoodameenabdulla, 1,3 jegadeeshraman, 1 chiaweiphan, 1,2 umahranikuppusamy, 1,3 shahramgolbabapour, 2,3 andvikineswarysabaratnam 1,3. The effect of nicotine on ethanolinduced gastric ulcers. Ganoderma lucidum pharmacopuncture for teating ethanol. Exposure of rats to ethanol resulted in gastric mucosal injury and a high index of ulcer. The number of proliferating and apoptotic cells, the mucosal mucus and prostaglandin e 2 pge 2 level were also determined. Phycobiliproteins of arthrospira spirulina maxima have attracted attention because of their potential therapeutic antioxidant properties. As shown in figure 1, the ethanol 96% administration induced extensive long and hemorrhagic gastric ulcers in the rat. Diazoxide, a katp channel opener, prevented ethanolinduced. Results showed that rats pretreated with omeprazole or j.
The anti ulcer activity of ethanolic extract of indigofera tinctoria fabaceae leaf eeit was investigated in indomethacin and ethanol induced ulcer models in wistar rats. Gastroprotective activity of aqueous carica papaya seed. Sapindaceae, in a concentration dependant manner 200600 mgkg inhibited gastric ulcers induced by oral administration of absolute ethanol. Further, the extract administration to rats resulted in an increase in levels of gastric glutathione and a decrease in alkaline phosphatase activity. All the animals were fasted for 36 hours before administration of ethanol. Effect of cardiospermum halicacabum on ethanolinduced.
The rats were fasted for 24 h, the separate groups. Central ghrelin 44000 ngrat dosedependently reduced ethanolinduced gastric ulcers by 3977%. Materials and methods experimental animals adult male rats weighing between 150 g and 200 g bred in the pre clinical animal house of the college of medicine and health sciences, afe babalola university, adoekiti were used. Protective effect of falcaria vulgaris extract on ethanol induced gastric ulcer in rat ijpt. In acute toxicity study, a high dose of gkg did not manifest any toxicological signs in rats. Antiulcerogenic effect of camel milk against ethanol. One hour after ethanol administration blood samples were. Alphalipoic acid improves acetic acidinduced gastric ulcer. The aim of this study was to assess the possible antiulcerogenic activity of these phycobiliproteins exphy against ethanolinduced gastric ulcers in rats. Santha maria1, surya devarakonda 1, ajay kumar tv 2 and n. Conventional histology and immunohistochemistry for ghrelin, gastrin, and somatostatin were performed on gastric specimens from representative rats.
Moreover, the alcoholinduced decrease in stomach antioxidant enzyme activity found in the ulcer control group was prevented by exphy. Antiulcer and antioxidant activity of moringa oleifera. Research article gastroprotective effects of lion s mane mushroom hericium erinaceus bullfr. Antiulcer and antioxidant activity of moringa oleifera lam. Pdf gastroprotective effect of zingerone on ethanolinduced.
Therapeutic effect of momordica balsamina leaf extract on ethanolinduced gastric ulcer in wistar rats background. Gastric ulcer index, microscopic score, elevated dna fragmentation and chemiluminescence. Ethanolinduced gu in animal model resembles the pathophysiology of human ulcer. Antiulcerogenic activity of scutia buxifolia on gastric ulcers induced. Gastric ulcers were induced in sprague dawley rats using one oral dose of absolute ethanol 1.
Oral pretreatment with zingerone attenuated the number and the length of gastric lesions in a dosedepended manner p ethanolinduced gastric lesions as shown in figure 1, the ethanol 96% administration induced extensive long and hemorrhagic gastric ulcers in the rat. Thus, the current study aimed to investigate the potential protective effects of dio against ethanolinduced gastric injury in rats. Amelioration of ethanolinduced gastric ulcers in rats. Gastric ulcers were induced by ethanol 96%, 5 mlkg, po in male wistar rats and zingerone 50, 100, and 200 mgkg was administrated orally. Mechanisms of gastroprotective effects of ethanolic leaf. Therapeutic effect of momordica balsamina leaf extract on. Materials and methods experimental animals adult male rats weighing between 150 g and 200 g bred in the pre clinical animal house of the college of medicine and health sciences, afe babalola university, ado. Rats were killed either with gastritis alone or thereafter at day 1, 3 or 6 after ulcer induction. To evaluate the role of ala treatment on the healing of acetic acidinduced gastric ulcer, rats were given ala 35 mgkgday or saline for 3 days before the induction of ulcer and the treatment was continued twice daily for 2 days early or 10 days late until they were decapitated.
Pdf protective role of phoenix dactylifera fruit against. Pdf antiulcerogenic effect of cuphea ignea extract. Pdf gastroprotective effects of betanin against ethanol. They were kept in specially constructed cages to prevent coprophagia during and after the experiment. Mar 11, 2019 this study is aimed to evaluate the effect of zingerone on ethanolinduced gastric ulcers in rats. Ulcer can be induced by administration of hpylori, nonsteroidal antiinflammatory drugs and by environmental and life style factors prabhu and shivani 2014. Antiulcerogenic effect of cuphea ignea extract against. Gastric ulcer was induced in overnight fasted rats that. Mda contents were evaluated in ethanolinduced ulcer in vivo.
Diazoxide, a katp channel opener, prevented ethanol. Balakrishnan1 school of biomedicine 1, asia metropolitan university, g8, jalan kemacahaya 11, batu 9, 43200 cheras, selangor, malaysia. Seven groups of rats were orally pretreated with carboxymethylcellulose cmc as normal group, cmc as ulcer group, 20 mgkg of omeprazole. Antiulcer activity of swietenia mahagoni leaf extract in ethanolinduced gastric mucosal damage in rats. Gastric ulcer index, microscopic score, elevated dna fragmentation and chemiluminescence levels of the saline. Antiulcerogenic effect of camel milk against ethanol induced. Pdf amelioration of ethanolinduced gastric ulcers in rats. For acute toxicity test 300 mg kg 1 2pentadecanone was orally given to rats, followed by 2 weeks observation period to confirm the. Ethanolinduced rodent gastric ulcer model creative biolabs. This study is aimed to evaluate the effect of zingerone on ethanolinduced gastric ulcers in rats. Influence of gender difference and gastritis on gastric.
Seven groups of rats were orally pretreated with carboxymethylcellulose cmc as normal. Taken together, the findings of this research amply demonstrated that weac exerted appreciable gastroprotective effect against ethanolinduced gastric ulcer in rats. Methanol leaf extract of actinodaphne sesquipedalis. Original article aripiprazole an atypical antipsychotic. A doseeffect relation was constructed using the ethanolinduced gastric ulcer model in male wistar rats. The gastric ulcers were induced in rats of either sex weighing between 150 g by administrating absolute ethanol 8 mlkg.
Pdf antiulcer activity of swietenia mahagoni leaf extract. To explore the possible mechanisms of action, we examined antioxidant defense enzymes e. Studies on the mechanism of ethanolinduced gastric damage. Gastroprotective effect of zingerone on ethanolinduced gastric. Forty adult wistar rats of either sex were marked, weighed and randomly assorted into 5 groups ae with each group containing 8 rats. Gastric ulcers were induced by oral ingestion of ethanol. Substances other also been shown to induce microcirculatory abnormalithan nicotine could contribute to these adverse reac ties. Ghrelin protects against ethanolinduced gastric ulcers in. According to yonei and guth 1 the gastric submucosal microvascular disturbance resulting in local ische. See desquamated mucosal cells red arrows from the surface of epithelium and. Relationship between ethanolinduced gastritis and gastric ulcer. The aim of the present investigation is to evaluate the gastroprotective effects of ethanolic extracts of j. Antioxidant effects of some drugs on ethanolinduced ulcers.
Indomethacin and ethanol induced ulcer models the common parameter determined was ulcer index. Protective effect of falcaria vulgaris extract on ethanol. For each extract, adult wistar rats of either sex were marked, weighed and randomly assorted into eight groups with each group containing five rats. Within 1 min of contact, ethanol caused diffuse mucosal hyperemia. Groups six and seven had animals treated with folic acid 2 mgkg and 3 mgkg for twentyone days and omeprazole for. Gastroprotective effect of zingerone on ethanolinduced. Groups six and seven had animals treated with folic acid 2 mgkg and 3 mgkg for twentyone days and omeprazole for the penultimate seven days respectively. Pdf gastroprotective effect of zingerone on ethanol. Gastric emptying rate was calculated through the formula. To investigate the protective effects of berberine on ethanolinduced gastric ulcer in mice. The potentiating actions of cigarette smoking on ethanol.
840 1345 692 343 1573 1309 529 727 875 1575 409 972 1371 111 1343 311 1059 1293 1251 271 1368 1247 726 273 973 402 1085 154 1024 1350 634 541 579